Jacques Kallis is set to make his first one-day international appearance for nearly two years when South Africa take on Pakistan in Cape Town on Sunday.
The all-rounder last played for the Proteas in a 50-over game against New Zealand on February 29, 2012 but has since been rested to manage his workload.
The 38-year-old takes the place of Twenty20 captain Faf du Plessis and coach Russell Domingo is confident he will give South Africa another dimension in the three-match series.
"Jacques is a fantastic cricketer," he said. "What he brings to the side is a lot of calmness and experience.
"Our all-rounders have always been bowlers who can bat, he is equally good at both which is a massive plus for us.
"What AB (De Villiers) does in Tests, Kallis does in ODIs, it allows us to play the extra batsman."
Test skipper Graeme Smith also returns to the fold after leaving the recent series between the two teams in the United Arab Emirates with post-concussion syndrome.
The Proteas won that series 4-1 but Pakistan beat them on Friday night in Cape Town to ensure the Twenty20 clashes between the two sides ended with a win apiece.
The teams return to 50-over action on Sunday and Domingo is keen that they get on a good run of form with one eye already on the World Cup in 2015.
"We have played good one-day cricket in the last series in the United Arab Emirates, so I think we can take a lot of confidence, having beaten them in their conditions."
He added: "We want to continue with the momentum we are developing in one-day cricket.
"We want to start finalising the structures and the group of players that we go with.
"We are going to alternate our bowling attack, there will be one or two guys that will need a break with another three games coming up against India.
"It's all about giving some of the fringe players some game time and experience."
Pakistan paceman Mohammad Irfan did not make the trip to South Africa due to injury while Misbah-ul-Haq will return to captain the ODI side.